The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about side effects, interactions and indications. Key takeaways Metoprolol is available in various immediate-release and extended-release formulations with similar drug interactions. Some examples of metoprolol interactions include monoamine oxidase inhibitors (MAOIs), drugs that slow the heart rate, and drugs that affect an enzyme called CYP2D6. Find patient medical information for Metoprolol (Lopressor, Toprol XL, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Metoprolol interacts with hundreds of medications. Learn which interactions are most dangerous — from antidepressants to calcium channel blockers — and what to tell your doctor. Does metoprolol interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker. Metoprolol has potential interactions with common medications, including CYP2D6 inhibitors and drugs that lower heart rate or blood pressure. 580 medications are known to interact with metoprolol. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings. Metoprolol is a medication for high blood pressure and heart issues, but it can interact with other drugs, leading to unexpected effects. Learn which combinations to avoid for safer treatment. Metoprolol is one of the most popular beta-blockers in the U.S., but interactions are common. Here are the top Metoprolol interactions you should know about.